Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics.
نویسندگان
چکیده
We screened for new structural non-coding RNAs (ncRNAs) in the genome sequence of the yeast Saccharomyces cerevisiae using computational comparative analysis of genome sequences from five related species of Saccharomyces. The screen identified 92 candidate ncRNA genes. Thirteen showed discrete transcripts when assayed by northern blot. Of these, eight appear to be novel ncRNAs ranging in size from 268 to 775 nt, including three new H/ACA box small nucleolar RNAs.
منابع مشابه
Computational identi®cation of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics
We screened for new structural non-coding RNAs (ncRNAs) in the genome sequence of the yeast Saccharomyces cerevisiae using computational comparative analysis of genome sequences from ®ve related species of Saccharomyces. The screen identi®ed 92 candidate ncRNA genes. Thirteen showed discrete transcripts when assayed by northern blot. Of these, eight appear to be novel ncRNAs ranging in size fro...
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In Nucleic Acids Res. [REF], we issued a correction for our article, Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics (Nucleic Acids Res. 31: 4119-4128, 2003). This paper reported eight new noncoding RNA genes in yeast, named RUF1 through RUF8, for “RNA of Unknown Function.” We subsequently found that we cannot verify the transcription of three...
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ورودعنوان ژورنال:
- Nucleic acids research
دوره 31 14 شماره
صفحات -
تاریخ انتشار 2003